DMCA. Copyrighted Work that you can Claim.
Base have 820 524 books.
Search: 


๐Ÿ“™ The Platelet by E. Edward Bittar and Eduardo G. Lapetina (Eds.) โ€” free download


Platelets have been an important model system in which to study various aspects of signal transduction. In spite of the fact that platelets are anucleated cells, it has been possible to assess the relationship between receptors, transducers and effectors, and specific platelet physiological responses. As a consequence, discrete biochemical events can be related to shape change, aggregation, and secretion. In addition to undergoing these internal biochemical changes, activated platelets express glycoproteins receptors for adhesive proteins on their surfaces; these help consolidation of the initial platelet aggregate to stop bleeding and start repair. When this protective action of platelets is exaggerated, a pathological situation arises. Abnormal platelet function is associated with thrombosis, atherosclerosis, and bleeding disorders.
This book deals with the most important aspects of platelet signal transduction that have been revealed in the past few years. Emphasis is given to knowledge gained in the area of glycoprotein receptors or integrins that bind adhesive proteins and play a crucial role in thrombosis. One of these integrins also serves as a collagen receptor on platelets. Collagen and thrombin are primary activators at sites of vascular injury. The main thrombin receptor recently was recognized as a seven trans-membrane domain receptor, and attention is now focused on the development of thrombin receptor antagonists that might prove to be useful in treatment of thrombosis and restenosis. The formation and release of thromboxane A2 n activated platelets help to recruit additional platelets to the injury site; the receptor for thromboxane A2 is a newly discovered seven trans-membrane domain receptor that is also covered in this book.
The coupling of platelet receptors to the effectors or second-messenger-producting enzymes is mostly through heterotrimeric and low molecular weight GTP-binding proteins, which have an important role in the stimulation or inhibition of platelet effectors. Two chapters deal with the role of GTP-binding proteins in human platelets. Several chapters are devoted to the effectors, including phospholipases C, A2, D, and phosphatidylinositol 3-kinase; the mobilization of Ca2+; and the formation of cAMP, cGMP, nitric oxide, and the role of the NA+/K+ exchanger. This is integrated with information on the activation of important protein kinases - that is, protein kinase C, Ca2+ -calmodulin-dependent protein kinases, cAMP and cGMP-dependent kinases, and tyrosine kinases - and on how these activities lead to changes in platelet cytoskeleton to cause shape change, aggregation, and secretion.


About book:

About file:

  • File size: 8 243 993
  • Format: pdf


Security code:
Download button

Similar books results


Platelet-Activating Factor
Platelet-Activating Factor pdf free by Henson P.M.

Platelet-activating factor (PAF) is a phospholipid mediator with a very broad spectrum of potential biologic activities. Although early studies focused on its likely role in acute, IgE-mediated allergic reactions or as a naturally occurring antihypertensi...

Platelet Factor 4-CXCL4
Platelet Factor 4-CXCL4 epub download by Neufeld G., Vadasz Z., Akiri G.

Platelet factor 4 (PF4) is a heparin-binding pisasu CXC chemokine, which is expressed in megakaryocytes and stored in the a granules of platelets. However, other cell types such as activated human leukocytes can also synthesize PF4. PF4 does not share cer...

Handbook of Platelet Physiology and Pharmacology
Handbook of Platelet Physiology and Pharmacology pdf free by Gundu H.R. Rao

Handbook of Platelet Physiology and Pharmacology represents the first comprehensive work to review blood platelet biochemistry, physiology, pharmacology and function. This edited volume provides up-to-date information on how platelets function, the bioche...

Platelets and Megakaryocytes: Volume 1: Functional Assays
Platelets and Megakaryocytes: Volume 1: Functional Assays (Vol.1 ) pdf free by Jane A. May, Stanley Heptinstall (auth.), Jonathan M. Gibbins, Martyn P. Mahaut-Smith (eds.)

Platelets are an essential element of the body's hemostasis system, and yet, through their involvement in thrombosis, are also a major cause of morbidity and mortality. Platelets have a limited lifespan and must be continually manufactured by their precur...

Platelets and Megakaryocytes: Volume 2: Perspectives and Techniques
Platelets and Megakaryocytes: Volume 2: Perspectives and Techniques (Vol.2 ) download pdf by Donna Woulfe, Jing Yang, Nicolas Prevost, Peter Oโ€™Brien, Ryan Fortna (auth.), Jonathan M. Gibbins, Martyn P. Mahaut-Smith (eds.)

Platelets are an essential element of the body's hemostasis system, and yet, through their involvement in thrombosis, are also a major cause of morbidity and mortality. Platelets have a limited lifespan and must be continually manufactured by their precur...

Platelets in Hematologic and Cardiovascular Disorders: A Clinical Handbook
Platelets in Hematologic and Cardiovascular Disorders: A Clinical Handbook download pdf by Paolo Gresele, Valentin Fuster, Jose A. Lopez, Clive P. Page, Jos Vermylen

A rapid increase in our understanding of the biology of platelets and their role in disease in recent years has been paralleled by increasing successes with established platelet-modifying therapies in many clinical conditions. This text focuses on the cli...

Platelets and Megakaryocytes: Volume 1: Functional Assays
Platelets and Megakaryocytes: Volume 1: Functional Assays epub download by Jane A. May, Stanley Heptinstall (auth.), Jonathan M. Gibbins, Martyn P. Mahaut-Smith (eds.)

Platelets are an essential element of the body's hemostasis system, and yet, through their involvement in thrombosis, are also a major cause of morbidity and mortality. Platelets have a limited lifespan and must be continually manufactured by their precur...

Platelets and Megakaryocytes: Volume 2: Perspectives and Techniques
Platelets and Megakaryocytes: Volume 2: Perspectives and Techniques free download by Donna Woulfe, Jing Yang, Nicolas Prevost, Peter Oโ€™Brien, Ryan Fortna (auth.), Jonathan M. Gibbins, Martyn P. Mahaut-Smith (eds.)

Platelets are an essential element of the body's hemostasis system, and yet, through their involvement in thrombosis, are also a major cause of morbidity and mortality. Platelets have a limited lifespan and must be continually manufactured by their precur...

Platelet Glycoprotein IIb IIIa Inhibitors in Cardiovascular Disease (Contemporary Cardiology)
Platelet Glycoprotein IIb IIIa Inhibitors in Cardiovascular Disease (Contemporary Cardiology) epub download by A. Michael Lincoff

The first comprehensive, definitive, and detailed overview of the preclinical and clinical development of the class of glycoprotein IIb/IIIa receptor antagonists. Written by the scientists who discovered and characterized this class of receptors, invented...

Platelets in Hematologic and Cardiovascular Disorders: A Clinical Handbook
Platelets in Hematologic and Cardiovascular Disorders: A Clinical Handbook free pdf by Paolo Gresele, Valentin Fuster, Jose A. Lopez, Clive P. Page, Jos Vermylen

A rapid increase in our understanding of the biology of platelets and their role in disease in recent years has been paralleled by increasing successes with established platelet-modifying therapies in many clinical conditions. This text focuses on the cli...