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Content:
Chapter 1 Aging of the Human Neuromuscular System: Pathological Aspects (pages 1–32): W. King Engel and Valerie Askanas
Chapter 2 Aging of the Human Neuromuscular System: Clinical Considerations (pages 33–54): W. King Engel and Valerie Askanas
Chapter 3 Aging of the Human Neuromuscular System: Patient Vignettes (pages 55–80): W. King Engel, Shalini Mahajan and Valerie Askanas
Chapter 4 Mitochondrial Changes in Aging with Particular Reference to Muscle, and Possible Clinical Consequences (pages 81–88): Salvatore Dimauro, Eric Schon and Michio Hirano
Chapter 5 Protein Degradation in Aging Cells and Mitochondria: Relevance to the Neuromuscular System (pages 89–96): Jenny K. Ngo and Kelvin J. A. Davies
Chapter 6 Human Muscle Protein Metabolism in Relation to Exercise and Aging: Potential Therapeutic Applications (pages 97–108): Micah J. Drummond and Blake B. Rasmussen
Chapter 7 Pathogenesis of Sporadic Inclusion?Body Myositis: Role of Aging and Muscle?Fiber Degeneration, and Accumulation of the Same Proteins as in Alzheimer and Parkinson Brains (pages 109–145): Valerie Askanas, W. King Engel and Anna Nogalska
Chapter 8 Inflammatory and Autoimmune Features of Inclusion?Body Myositis (pages 146–158): Marinos C. Dalakas
Chapter 9 Sporadic Inclusion?Body Myositis: Clinical Symptoms, Physical Findings, and Diagnostic Investigations (pages 159–167): Frank L. Mastaglia
Chapter 10 Pathologic Diagnostic Criteria of Sporadic Inclusion?Bodyc Myositis and Hereditary Inclusion?Body Myopathy Muscle Biopsies (pages 168–174): Valerie Askanas and W. King Engel
Chapter 11 Function and Mutations of the GNE Gene Leading to Distal Myopathy with Rimmed Vacuoles/Hereditary Inclusion?Body Myopathy, Animal Models, and Potential Treatment (pages 175–190): May Christine V. Malicdan, Satoru Noguchi and Ichizo Nishino
Chapter 12 GNE Myopathy (Hereditary Inclusion?Body Myopathy/Distal Myopathy with Rimmed Vacuoles): Clinical Features and Epidemiology (pages 191–198): Zohar Argov, Ichizo Nishino and Ikuya Nonaka
Chapter 13 Consequences of the hereditary inclusion?body myopathy?characteristic GNE mutations on muscle proteins in vivo and in vitro (pages 199–205): Aldobrando Broccolini and Massimiliano Mirabella
Chapter 14 Function and Structure of VCP Mutations Leading to Inclusion?Body Myopathy Associated with Paget Disease of Bone and Frontotemporal Dementia (pages 206–218): Cezary Wojcik
Chapter 15 Clinical Spectrum of VCP Myopathy, Paget Disease, and fronTotemporal Dementia: Experimental Models and Potential Treatments (pages 219–229): Virginia E. Kimonis, Eric Dec, Mallikarjun Badadani, Angele Nalbandian, Jouni Vesa, Vincent Caiozzo, Douglas Wallace, Barbara Martin, Charles Smith and Giles D. Watts
Chapter 16 Drosophila and Mouse Models of Hereditary Myopathy Caused by Mutations in VCP/p97 (pages 230–239): Nisha M. Badders and J. Paul Taylor

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  • Language: English
  • ISBN: 9781405196468,9781444398311

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