DMCA. Copyrighted Work that you can Claim.
Base have 820 524 books.
Search: 


πŸ“™ Mass Spectrometry in Sports Drug Testing: Characterization of Prohibited Substances and Doping Control Analytical Assays (Wiley - Interscience Series on Mass Spectrometry) by Mario Thevis β€” epub download


"This book provides a detailed overview about the mass spectrometry of numerous classes of therapeutics and agents relevant to doping control laboratories, the necessity of various analyzers enabling the detection of low- and high molecular weight drugs as well as the discrimination between endogenously produced and synthetically derived compounds. Typical assays including sample preparation, chromatographic separation and mass spectrometric analysis are presented highlighting the comprehensiveness of drug testing in modern doping control laboratories"--Provided by publisher. Read more... Content: History of sports drug testing -- Historical attempts of artificial performance enhancement -- Background and rationale of doping controls -- Cheating -- Health issues -- Ethical issues -- Early detection methods: possibilities and limitations of assays without mass spectrometry -- First applications using chemical and biological approaches in horse doping control -- First applications using chemical and biological approaches in horse doping control -- First applications using chemical approaches in human doping control -- Introduction of mass spectrometry to doping control analysis -- First approaches and adverse analytical findings -- Progressino of analytical methods -- Mass spectrometry and the list of prohibited substances and methods of doping -- Criteria for the mass spectrometric identification of prohibited compounds -- Low molecular weight analytes -- High molecular weight analytes -- Modern mass spectrometers in doping controls: advances and disadvantates of available techniques -- Ionization techniques in routine doping controls -- Mass analyzers in routine doping controls -- Structure characterization of low molecular weight target analytes--electron ionization -- Stimulants -- Narcotics -- Anabolic androgenic steroids -- Unsaturated 3-keto-steroids -- a, ß-saturated ketosteroids -- 3-keto-1,4-diene, 3-keto-4,6-diene, and 3-keto-4,9(11)-diene steroids -- Steroid derivatization -- Selective androgen receptor modulators (SARMs) -- 2-quinolinone-based SARMs -- Hydroxybicyclic hydantoin-derived SARMs -- Diuretics -- Thiazide-derived drugs -- Benzoic acid-derived loop diuretics -- Potassium-sparing diuretics -- ΓŸβ‚‚-agonists -- ß-receptor blocking agents -- Calcium-channel modulators (RYCALS) -- Carbohydrate-based agents -- Mannitol -- Glycerol -- Hydroxyethl starch and dextran -- Structure characterization of low molecular weight target analytes: electrospray ionization -- Stimulants -- Narcotics -- Anabolic androgenic steroids -- z, ß-saturated 3-keto-steroids -- 3-keto-4-ene and 3keto-1-ene steroids -- 3-keto-1,4-diene steroids -- 3-keto-4,6-diene steroids -- 3-keto-4,9-diene steroids -- 3-keto-4,9,1-triene steroids -- Stanozolol -- Selective androgen receptor modulators (SARMs) -- Arylpropionamide-derived SARMs -- Hydroxybicyclic hydantoin-derived SARMs -- 2-quinolinone-derived SARMs -- Diuretics -- Thiazide-derived drugs -- Benzoic acid-derived loop diuretics -- Potassium-sparing diuretics -- ΓŸβ‚‚-agonists -- Calcium-channel modulators (RYCALS) -- Peroxisome-proliferator activated receptor- (PPAR) and adenosine monophosphate activated protein kinase (AMPK) agonists -- Hypoxia-inducible factor (HIF)-stabilizers and sirtuin activators -- HIF-stabilizers -- Sirtuin activators -- ß-receptor blocking agents -- Glucuronic acid and sulfate conjugates of target analytes. Structure characterization of high molecular weight target analytes: electrospray ionization -- Human chorionic gonadotrophin (hCG) -- Erythropoietins (EPO) -- Synacthen -- Insulins -- Hemoglobin-based oxygen carriers (HBOCs) -- Human growth hormone (hGH) -- Sermorelin (Geref) -- Insulin-like growth factor-1 (IGF-1) -- Gonadorelin (LHRH) -- Modern mass spectrometry-based analytical assays -- GC-MS and isotope ratio mass spectrometry -- Stimulants/narcotics -- Anabolic androgenic steroids -- Diuretics -- ΓŸβ‚‚-agonists and ß-receptor blocking agents -- Carbohydrate-based agents -- LC-MS/MS -- Stimulants/narcotics/ΓŸβ‚‚-agonists/ß-receptor blocking agents -- Anabolic androgenic steroids/corticosteroids/hormone antagonists and modulators -- Masking agents (including diuretics) -- Peptide hormones <10kDa including insulins, synacthen, gonadorelin, IGF-1 -- Hemoglobin-based oxygen carriers -- Human chorionic gonadotrophin (hCG) -- Limitations and perspectives of mass spectrometry-based procedures in doping control analysis -- Recombinant biomolecules -- Erythropoietin -- Human growth hormone -- Human insulin and IFG-1 -- Unknown compounds -- Profiling of urine and/or blood -- Alternative specimens. Abstract: Mass spectrometry is a major tool to characterize, identify, and detect hundreds of known and unknown drugs. Read more...

About book:

About file:

  • File size: 6 498 497
  • Format: pdf


Security code:
Download button

Similar books results


Mass Spectrometry in Drug Metabolism and Pharmacokinetics
Mass Spectrometry in Drug Metabolism and Pharmacokinetics download pdf by Ragu Ramanathan

Evolving role of mass spectrometry in drug discovery and development / Dil M. Ramanathan and Richard M. LeLacheur -- Quantitative bioanalysis in drug discovery and development: principles and applications / Ayman El-Kattan, Chris Holliman, and Lucinda H. ...

Protein and Peptide Mass Spectrometry in Drug Discovery
Protein and Peptide Mass Spectrometry in Drug Discovery epub download by Michael L. Gross, Guodong Chen, Birendra Pramanik

The book that highlights mass spectrometry and its application in characterizing proteins and peptides in drug discoveryAn instrumental analytical method for quantifying the mass and characterization of various samples from small molecules to large protei...

Mass Spectrometry for Drug Discovery and Drug Development
Mass Spectrometry for Drug Discovery and Drug Development free download by Dominic M. Desiderio, Nico M. M. Nibbering(eds.)

With coverage of the latest mass spectrometry technology, this book explains how mass spectrometry can be used to enhance almost all phases of drug discovery and drug development, including new and emerging applications. The book's fifteen chapters have b...

Using Mass Spectrometry for Drug Metabolism Studies
Using Mass Spectrometry for Drug Metabolism Studies download pdf by Walter A. Korfmacher

The first edition of this now classic work helped to establish mass spectrometry as the premier tool for drug metabolism studies. Completely rewritten from start to finish, Using Mass Spectrometry for Drug Metabolism Studies, Second Edition brings medici...

Using Mass Spectrometry for Drug Metabolism Studies
Using Mass Spectrometry for Drug Metabolism Studies free pdf by Walter A. Korfmacher

Mass spectrometry (MS) is fast becoming the premier tool for analyzing various drug metabolism samples in the early phases of drug discovery and research. Introducing the newer, more powerful MS equipment and exploring new applications for using them, thi...

Using Mass Spectrometry for Drug Metabolism Studies, Second Edition
Using Mass Spectrometry for Drug Metabolism Studies, Second Edition download pdf by Walter A. Korfmacher

The first edition of this now classic work helped to establish mass spectrometry as the premier tool for drug metabolism studies. Completely rewritten from start to finish, Using Mass Spectrometry for Drug Metabolism Studies, Second Edition brings medicin...

Mass Spectrometry in Drug Discovery
Mass Spectrometry in Drug Discovery free pdf by David T. Rossi, Michael Sinz

Mass Spectrometry in Drug Discovery summarizes the theory, instrumentation, techniques, and application of mass spectrometry and atmospheric pressure ionization to screening, evaluating, and improving the performance and quality of drug candidates. It pro...

Clinical Applications of Mass Spectrometry in Drug Analysis: Methods and Protocols
Clinical Applications of Mass Spectrometry in Drug Analysis: Methods and Protocols free pdf by Uttam Garg (eds.)

This volume describes methods and protocols for a number of drugs and toxins in a stepwise manner. Chapters in the book cover a wide array of topics such as: quantitation of Flecainide, Mexiletine, Propafenone, and Amiodarone in Serum or Plasma; quantitat...

Mass Spectrometry in Drug Metabolism
Mass Spectrometry in Drug Metabolism pdf free by A. Donetti, L. G. Dring, P. C. Hirom, R. T. Williams (auth.), Alberto Frigerio, Emilio L. Ghisalberti (eds.)

When a dose of drug is administered, three main phases of drug action may be distingushed. In the "pharmaceutical" phase the dosage form disintegrates, the active substance dissolves and becomes available for absorption. The second phase ("pharmacoΒ­ kinet...