DMCA. Copyrighted Work that you can Claim.
Base have 820 524 books.
Search: 


📙 Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists, Second Edition by Robert A. Copeland(auth.) — epub download


Offers essential guidance for discovering and optimizing novel drug therapies

Using detailed examples, Evaluation of Enzyme Inhibitors in Drug Discovery equips researchers with the tools needed to apply the science of enzymology and biochemistry to the discovery, optimization, and preclinical development of drugs that work by inhibiting specific enzyme targets. Readers will applaud this book for its clear and practical presentations, including its expert advice on best practices to follow and pitfalls to avoid.

This Second Edition brings the book thoroughly up to date with the latest research findings and practices. Updates explore additional forms of enzyme inhibition and special treatments for enzymes that act on macromolecular substrates. Readers will also find new discussions detailing the development and application of the concept of drug-target residence time.

Evaluation of Enzyme Inhibitors in Drug Discovery begins by explaining why enzymes are such important drug targets and then examines enzyme reaction mechanisms. The book covers:

  • Reversible modes of inhibitor interactions with enzymes
  • Assay considerations for compound library screening
  • Lead optimization and structure-activity relationships for reversible inhibitors
  • Slow binding and tight binding inhibitors
  • Drug-target residence time
  • Irreversible enzyme inactivators

The book ends with a new chapter exploring the application of quantitative biochemical principles to the pharmacologic evaluation of drug candidates during lead optimization and preclinical development.

The Second Edition of Evaluation of Enzyme Inhibitors in Drug Discovery continues to offer a treatment of enzymology applied to drug discovery that is quantitative and mathematically rigorous. At the same time, the clear and simple presentations demystify the complex science of enzymology, making the book accessible to many fields? from pharmacology to medicinal chemistry to biophysics to clinical medicine.Content:
Chapter 1 Why Enzymes as Drug Targets? (pages 1–23):
Chapter 2 Enzyme Reaction Mechanisms (pages 25–55):
Chapter 3 Reversible Modes of Inhibitor Interactions with Enzymes (pages 57–121):
Chapter 4 Assay Considerations for Compound Library Screening (pages 123–168):
Chapter 5 Lead Optimization and Structure–Activity Relationships for Reversible Inhibitors (pages 169–201):
Chapter 6 Slow Binding Inhibitors (pages 203–244):
Chapter 7 Tight Binding Inhibition (pages 245–285):
Chapter 8 Drug–Target Residence Time (pages 287–344):
Chapter 9 Irreversible Enzyme Inactivators (pages 345–382):
Chapter 10 Quantitative Biochemistry in the Pharmacological Evaluation of Drugs (pages 383–469):

About book:

About file:

  • File size: 10 510 262
  • Format: pdf


Security code:
Download button

Similar books results


Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (Methods of Biochemical Analysis)
Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (Methods of Biochemical Analysis) free pdf by Robert A. Copeland

Vital information for discovering and optimizing new drugs"Understanding the data and the experimental details that support it has always been at the heart of good science and the assumption challenging process that leads from good science to drug discove...

ADMET for Medicinal Chemists: A Practical Guide
ADMET for Medicinal Chemists: A Practical Guide pdf free by Katya Tsaioun, Steven A. Kates

This book guides medicinal chemists in how to implement early ADMET testing in their workflow in order to improve both the speed and efficiency of their efforts. Although many pharmaceutical companies have dedicated groups directly interfacing with drug d...

Lead Optimization for Medicinal Chemists: Pharmacokinetic Properties of Functional Groups and Organic Compounds
Lead Optimization for Medicinal Chemists: Pharmacokinetic Properties of Functional Groups and Organic Compounds pdf free by Dr. Florencio Zaragoza Dorwald(auth.)

Small structural modifications can significantly affect the pharmacokinetic properties of drug candidates. This book, written by a medicinal chemist for medicinal chemists, is a comprehensive guide to the pharmacokinetic impact of functional groups, the p...

Natural Products: Drug Discovery and Therapeutic Medicine
Natural Products: Drug Discovery and Therapeutic Medicine download pdf by Arnold L. Demain, Lixin Zhang (auth.), Lixin Zhang PhD, Arnold L. Demain PhD (eds.)

Although the natural product drug discovery programs of the large drug companies are now equaled by programs for the high throughput screening of synthetic compounds generated through combinatorial chemistry, natural compounds still hold great promise to ...

ADMET for Medicinal Chemists: A Practical Guide
ADMET for Medicinal Chemists: A Practical Guide epub download by Katya Tsaioun, Steven A. Kates

This book guides medicinal chemists in how to implement early ADMET testing in their workflow in order to improve both the speed and efficiency of their efforts. Although many pharmaceutical companies have dedicated groups directly interfacing with drug d...

Drug Discovery for the Treatment of Addiction : Medicinal Chemistry Strategies
Drug Discovery for the Treatment of Addiction : Medicinal Chemistry Strategies free download by Brian S. Fulton

With addiction a key target for drug discovery efforts, this book fills an important and timely need for medicinal chemists who need to understand complex neuroscience issues. The author illustrates medicinal chemistry's prominent role in treating addict...

Biostatistics for medical and biomedical practitioners : an interpretative guide for medicine and biology
Biostatistics for medical and biomedical practitioners : an interpretative guide for medicine and biology epub download by Julien I. E. Hoffman MD FRCP

Biostatistics for Practitioners: An Interpretative Guide for Medicine and Biology deals with several aspects of statistics that are indispensable for researchers and students across the biomedical sciences. The book features a step-by-step approach, focus...

Chemistry and the Chemical Industry. A Practical Guide for Non-Chemists
Chemistry and the Chemical Industry. A Practical Guide for Non-Chemists download pdf by Robert A. Smiley, Harold L. Jackson

As chemical companies strive to be more competitive in the world economy, it is essential that their employees, including sales and marketing personnel, as well as administrative support groups understand the basic concepts of the science upon which the i...

Chemistry and the Chemical Industry: A Practical Guide for Non-Chemists
Chemistry and the Chemical Industry: A Practical Guide for Non-Chemists pdf free by Smiley R. A., Jackson H. L.

he authors provide a clear concise presentation of the key issues behind the discipline of chemistry and the chemical industry. Designed specifically for self-study at the reader's own pace Chemistry and the Chemical Industry: A Practical Guide for Non-Ch...