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Volume 1

Methods and Applications of Statistics in Clinical Trials, Volume 1: Concepts, Principles, Trials, and Designs successfully upholds the goals of the Wiley Encyclopedia of Clinical Trials by combining both previously-published and newly developed contributions written by over 100 leading academics, researchers, and practitioners in a comprehensive, approachable format. The result is a succinct reference that unveils modern, cutting-edge approaches to acquiring and understanding data throughout the various stages of clinical trial design and analysis.

Volume 2

Featuring newly-written material as well as established literature from the Wiley Encyclopedia of Clinical Trials, this book provides a timely and authoritative review of techniques for planning clinical trials as well as the necessary inferential methods for analyzing collected data.

This comprehensive volume features established and newly-written literature on the key statistical principles and concepts for designing modern-day clinical trials, such as hazard ratio, flexible designs, confounding, covariates, missing data, and longitudinal data. Examples of ongoing, cutting-edge clinical trials from today's research such as early cancer & heart disease, mother to child human immunodeficiency virus transmission, women's health initiative dietary, and AIDS clinical trials are also explored.

Content:
Chapter 1 Chairman's Opening Remarks (pages 1–2): O. G Edholm
Chapter 2 A Critical Survey of Methods Available for the Measurement of Human Peripheral Blood Flow (pages 3–22): Alan C. Burton
Chapter 3 A Method for Recording and a Study of the Venous Occlusive Technique for Measuring the Time Course of the Rate of Inflow and the Time Course of the Rate of Outflow in the Finger Tip of Man During a Single Pulse Cycle (pages 23–44): G. E. Burch
Chapter 4 The Electrical Strain Gauge Method for Measurement of Peripheral Circulation in Man (pages 45–57): R. J. Whitney
Chapter 5 The Transparent Chamber Technique for Observation of the Peripheral Circulation, as Studied in Mice (pages 58–67): Glenn H. Algire
Chapter 6 Differentzal Secretion of Adrenaline and Noradrenaline from the Suprarenal Gland (pages 68–74): U. S. van Euler
Chapter 7 The Effect of Adrenaline and Noradrenaline on the Blood Flow Through Human Skeletal Muscle (pages 75–91): R. F. Whelan
Chapter 8 Changes in Peripheral Circulation with Exposure to Cold (pages 92–104): Loren D. Carlson
Chapter 9 The Response to Cold in the Range 0–10°C. (pages 105–114): A. D. M. Greenfield
Chapter 10 Factors Concerned in the Regulation of Skin Blood Flow (pages 115–121): D. McK. Kerslake and K. E. Cooper
Chapter 11 Blood Flow Response to Temperature and Other Factors (pages 122–131): H. Barcroft and A. C. Dornhorst
Chapter 12 Observations on the Neurohistology of Cutaneous Blood Vessels (pages 132–142): G. Weddell and W. Pallie
Chapter 13 Some Aspects of the Reflex Control of the Cutaneous Circulation (pages 143–152): K. E. Cooper and D. McK. Kerslake
Chapter 14 The Problem of Vasomotor Denervation (pages 153–166): A. B. Hertzman, W. C. Randall, J. W. Cox, W. F. Alexander and K. B. Coldwater
Chapter 15 Vascular Reactivity Following Sympathectomy (pages 167–172): R. T. Grant
Chapter 16 Some Anatomical Observations on Peripheral Ischbmia in Man (pages 173–184): J. Henry Dible
Chapter 17 The Mechanism of the Raynaud's Phenomenon in Patients with High Serum Titres of Cold Agglutinins (pages 185–191): J. T. Shepherd
Chapter 18 Visceral Activity and Peripheral Circulation in the Spinal Man (pages 192–203): L. Guttmann
Chapter 19 Some Aspects of Functional Disorders of the Circulation (pages 204–210): P. Martin

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